LOS ANGELES (AP) — Destiny Littleton scored 18 points with six assists as Southern California pulled off a program-defining victory Sunday with a 55-46 upset victory over No. 2 Stanford.

Okako Adika scored 11 points with 11 rebounds, while Taylor Bigby and Kayla Williams added nine points each as the Trojans set the tone with their defense and held on late to end a 14-game losing streak against the Cardinal who had won 51 straight against unranked opponents.

It was USC’s first victory over Stanford since the 2014 Pac-12 Tournament.

USC (13-4, 3-3 Pac-12) held Stanford to four points in the first quarter, its low for any period this season. The Trojans led by as many as 11 points early in the fourth quarter before closing out the victory just eight days after a heartbreaking loss to then-No. 12 UCLA.

Cameron Brink scored 11 points with 14 rebounds for Stanford (17-2, 5-1), which saw its 12-game winning streak come to an end. The defeat also ended the Cardinal’s 39-game winning streak over Pac-12 competition.

Haley Jones had 12 rebounds for Stanford but was held to eight points after she entered with 13.3 per game.

Stanford held USC to 27.3% shooting from the field, but the Trojans made up the difference by going 8 of 19 from 3-point range and making 17 of 26 free throws. Stanford was 4 of 21 from distance and 8 of 10 from the line..

USC looked up for the task early with a suffocating defense that forced six turnovers in the first quarter and held Stanford to 2 of 10 shooting in the opening 10 minutes, while taking an 11-4 lead.

Stanford rallied to tie the game 19-19 with 1:09 left in the first half before a five-point USC burst put the Trojans up 24-19 at the break.

USC made a statement to close the third quarter. Clarice Akunwafo blocked Stanford’s Lauren Betts with three seconds left in the period. Williams used the time to get into the front court and drain a 24-footer at the buzzer for a 43-33 advantage, USC’s largest of the game to that point.

USC nearly held Stanford to single digits in the fourth quarter as well, allowing 13, with four of those coming in the closing seconds. The only other time Stanford was held to single digits in a quarter this season was a seven-point performance in the fourth quarter in its only other defeat vs. South Carolina on Nov. 20

THE TAKEAWAY

Stanford: After a victory over No. 8 UCLA, followed by the unexpected loss at USC, another challenge awaits for the Cardinal with a home test against No. 10 Utah on Friday to open a run of four consecutive home games.

USC: The top defense in the Pac-12 (52.0 points per game entering Sunday) has been making more statements. USC gave up a combined 10 first-quarter points to Cal (six) and Stanford (four) in a span of three days.

UP NEXT

Stanford: Home against Utah on Friday

USC: At Washington State on Friday